Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere

J Med Chem. 1993 Jan 22;36(2):288-91. doi: 10.1021/jm00054a014.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • HIV Protease Inhibitors / chemical synthesis*
  • HIV Protease Inhibitors / pharmacology
  • Humans
  • Hydroxyurea / analogs & derivatives*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Urea / analogs & derivatives*
  • Urea / chemical synthesis
  • Urea / pharmacology

Substances

  • Antiviral Agents
  • HIV Protease Inhibitors
  • Urea
  • SC 52151
  • Hydroxyurea